A Correlative Model to Predict In Vivo AUC for Nanosystem Drug Delivery with Release Rate-Limited Absorption
نویسندگان
چکیده
منابع مشابه
A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption.
PURPOSE Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. METHODS A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 5...
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ژورنال
عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences
سال: 2012
ISSN: 1482-1826,1482-1826
DOI: 10.18433/j3np5n